New products now available - 24/02/2017

 

Human Ang-2 ELISA kit                         873.080.048 / 096 / 192

 

 

Angiopoietin is part of the family of vascular growth factors that plays a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form preexisting blood cells. Angiogenesis proceeds through sprouting, endothelial cell migration, proliferation, and vessel destabilization and stabilization. They are responsible for assembling and disassembling the endothelial lining of blood vessels. Angiopoietin cytokines are involved with controlling microvascular permeability, vasodilation, and vasoconstriction by signaling smooth muscle cells surrounding vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4.

 

Angiopoietin-2 (Ang-2) is a key regulator of angiogenesis that exerts context-dependent effects on ECs. Ang-2 binds the endothelial-specific receptor tyrosine kinase 2 (Tie2) and acts as a negative regulator of Ang-1/Tie2 signaling during angiogenesis, thereby controlling the responsiveness of ECs to exogenous cytokines. Recent data from tumors indicate that under certain conditions Ang-2 can also promote angiogenesis.

 

Human VEGF165 ELISA Kit                      873.070.048 / 096 / 192

 

VEGF-A (Vascular Endothelial Growth Factor A) is a dimeric glycoprotein considered to be the main inducer of human blood vessels. It belongs to the VEGF family of related growth factors, along with VEGF-B, -C, -D (also known as FlGF) and PLGF (Placental Growth Factor). VEGF-A plays a crucial role in vasculogenesis, the process by which blood vessels are generated and angiogenesis, the expansion of an existing vascular bed by sprouting of new blood vessels as it acts as a highly specific mitogen for endothelial cells.  Angiogenesis typically occurs as a response to a stimulus such as tissue hypoxia or other stress and results in improved perfusion and increased oxygen delivery. Angiogenis is essential during pregnancy and in tissue growth and repair and is also a key underlying process in the pathogenesis of several major human diseases including cancer.

 

Accessory pack for ELISA set                 858.000.005

 

Material for optimal assay performance (quantity provided for 5x96 tests)

Contains : 5x96 wells strip plates + plate storage material / Coating Buffer 10X, 1 vial 5ml/ Wash Buffer 200X, 1 vial 25ml/ Blocking Buffer 5 vials 10ml/ Standard Dilution Buffer 10X, 1 vial 12.5ml/ Reconstitution Buffer 10X 1 vial 0.1 ml /Secondary Antibody Dilution Buffer, 1 vial 25 ml/ HRP Dilution Buffer, 2 vials 25 ml/ Stop reagent 5 vials 10 ml


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