Biologically Active Antibodies

Investigate your cellular assay systems using the Diaclone range of Biologically Active Monoclonal Antibodies.

Diaclone offers a broad range of biologically active, Azide Free antibodies suitable for induction, activation, neutralisation and inhibition studies.

Specificity (Anti-Human)

Clone

Azide Free

Biological Activity

CD2

B-E2

852.500.000

Inhibits mixed lymphocyte culture

CD3

B-B11

854.010.000

Induces T lymphocyte stimulation and proliferation

CD4

B-A1

854.030.000

Inhibits mixed lymphocyte culture

CD10

B-E3

854.090.000

Cytotoxic In association with rabbit complement on CD10+ cells

CD20

B-H20

854.150.000

Cytotoxic in association with complement on CD20 cells

CD21

B-E5

854.160.000

Induces human B-cell proliferation and competes with EBV for CD21 binding.

CD25

B-B10

852.000.000

Inhibits mixed lymphocyte culture

CD25

B-F2

852.010.000

Inhibits mixed lymphocyte culture

CD28

B-T3

854.220.000

Inhibits mixed lymphocyte culture. Co-stimulates T-cell proliferation

CD34 Class I

B-G25

854.240.000

Triggers KG-1a cell aggregation

CD40

B-B20

854.280.000

Stimulates B-cell proliferation together with IL-4

CD44

B-F24

852.600.000

Triggers T-lymphocyte aggregation. Enhances Hyaluronan binding to CD44

CD54

B-H17

852.690.000

Inhibits PHA stimulated T-cell proliferation

CD86

B-T7

854.450.000

Inhibits mixed lymphocyte culture

CD95

B-G27

853.000.000

Triggers Fas induced apoptosis

CD95

B-D29

853.030.000

Inhibits FasL induced apoptosis

CD102

B-T1

852.760.000

Inhibits cell adhesion and T-cell activation

CD106

B-K9

852.770.000

Inhibits cell attachment to VCAM-1

CD117

B-K15

854.510.000

Inhibits the KIT ligand induced proliferation of TF1 cell line

CD126

B-R6

852.030.000

Inhibits IL-6 induced proliferation of XG-1 cells

CD130

B-R3

852.060.000

Inhibits IL-6, IL-11, CNTF, LIF and OSM activities

CD130

B-K5

852.070.000

Inhibits CNTF activity. Inhibits OSM binding to gp130

CD130

B-P8

852.080.000

Inhibits CNTF activity and binding to gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation

CD130

B-P4

852.090.000

Inhibits IL-11 activity and binding to gp130, but not CNTF, LIF and OSM activities

CD130

B-S12

852.110.000

Activates cells carrying gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation

CD178

B-R17

853.070.000

Inhibits soluble CD178 induced apoptosis

CD184

B-R24

854.600.000

Inhibits HIV-1 infection

CD202b

B-B48

854.710.000

Inhibits Tek-L / Tek binding

CD253

B-S23

853.080.000

Enhances TRAIL induced apoptosis

CD253

B-T24

853.090.000

Inhibits TRAIL induced apoptosis

CD261

B-N36

854.850.000

Neutralizes TRAIL induced apoptosis on HEL cell line

CD262

B-K29

854.860.000

Neutralizes TRAIL induced apoptosis of U937 cell line

CD262

B-D37

854.870.000

Agonist: induced apoptosis on Jurkat cells. Enhances TRAIL induced apoptosis of U937 cell line

CD263

B-D44

854.890.000

Inhibits TRAIL binding to TRAIL R3

CDw218a

B-E43

854.900.000

Inhibits human IFNγ secretion induced by IL-18 stimulated cells

CDw218b

B-B46

854.910.000

Inhibits human IFNγ secretion induced by IL-18 stimulated cells

HLA Class I

W6/32

857.220.000

Inhibits the interaction between T cells and MHC molecules

IFN-γ

B-B1

855.000.005

Inhibits IFNγ induced proliferation

IL-1b

B-A15

855.010.005

Inhibits IL-1β induced proliferation on D10S murine cell line

IL-2

B-G5

855.020.005

Inhibits IL-2 induced proliferation on CTL-L2 murine cell line

IL-4

B-S4

855.030.005

Inhibits IL-4 induced proliferation on TF1 cells

IL-6

B-E8

855.050.005

Inhibits IL-6 induced proliferation on B9 cells

IL-8

B-K8

855.080.005

Inhibits IL-8 induced chemotaxis of human neutrophils

IL-10

B-S10

855.100.005

Inhibits IL-10 induced proliferation on MC/9 cell line

IL-12p35+p70

B-T21

855.120.005

Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes

IL-12p40+p70

B-P24

855.130.005

Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes

IL-13

B-B13

855.140.005

Inhibits IL-13 induced proliferation on TF1 cell line

IL-15

B-E29

855.220.005

Inhibits IL-15 induced proliferation on Kit 225 cell line

IL-17A

B-B51

853.910.005

Inhibits the bioactivity of IL-17A on keratinocytes cell line HaCaT (measurement of defensin-2 production)

IL-17F

B-F60

855.360.005

Neutralises the bioactivity of IL-17F on HT1080 cell line (measurement of IL-6 production)

IL-23

B-Z23

853.920.005

Inhibits the bioactivity of rhIL-23 on mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production)

NKp46

B-L46

855.490.000

The biological activity is measured by the ability of the coated antibody to induce degranulation of activated NK cells and to enhance IFNγ secretion by non-activated NK cells

NTR 1

B-N6

857.040.000

Inhibits neurotensin binding to its receptor

TNF-α

B-C7

855.150.005

Inhibits TNFα induced cytotoxicity on U937 cells

Visit www.diaclone.com for information about our full Monoclonal Antibody range for applications including Flow Cytometry, ImmunoHistochemistry, Immunoassay, Immunoflouresence and Western Blotting.